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Bacterial metabolites such as HPHPA (4-hydroxyphenylpropionic acid) and DHPPA can indicate Clostridia overgrowth, which has been associated with altered dopamine metabolism

Results: Our single-center MASLD study cohort included 382 patients, of whom 193 (50%) were male, with a mean age of 53 (15) years, and a mean BMI of 31.2 ( 6.8) kg/m 2

A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism