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Most importantly, in the CP-induced AKI model, 4.2.4 Targeting necroptosis in CP-induced AKI Given the central role of the necroptotic pathway and its associated inflammation in the pathogenesis of CP-induced AKI along with their potential role in AKI-to-CKD transition, multiple agents with anti-necroptotic activity were tested in the CP-induced AKI model

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