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Polymeric nanoparticle-encapsulated curcumin (nanocurcumin): a novel strategy for human cancer therapy

Some studies have proposed the hypothesis that the increase of mannose level in the CSF of PD patients may be directly related to the decreased MBL level that leads to decreased mannose binding, thus increasing the accumulation of free mannose in the CSF

This hypercatabolism is evident by our data demonstrating depletion of amino acids and upregulation of the urea cycle as judged by elevated levels of urea cycle metabolites such as citrulline

loss of lobular plates, architecture, and/or occurrence of cellular atypia

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