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Concomitantly, other cytokines such as IL-1 and , IL-10, IL-6, and others exhibited lower concentrations in Mda5 -/- bone marrow serum, while other cytokines like TNF and IFN showed no differences (Fig

Puerarin-loaded PLGA were orally administered to Sprague-Dawley rats, where pharmacokinetic analysis showed a 10.52-fold increase in plasma bioavailability and a 6.46-fold increase in brain puerarin accumulation compared to oral administration of free puerarin

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6A), COX2 (Fig

A substantial amount of evidence has shown dysregulation of FGFR signaling as a pathogenic mechanism and consequence of cancer, 93 and it is frequently detected to be highly expressed in HCC, contributing to tumorigenesis, progression, and drug resistance