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Preliminary evidence from cellular, animal, transcriptomic and metabolomic studies for the specific pathological contribution of GPT2 in COPD airway structural cells has emerged in recent years, but more clinical samples and functional validations are needed to establish its strength of action in patients and feasibility as a therapeutic target (109)

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233 Conversely, bone-derived FGF23 reflects mineralmetabolism disturbances and independently predicts incident DKD, adverse cardiovascular events and limb outcomes in diabetic individuals with peripheral arterial disease

Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection