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10.1074/jbc.M606676200 J

Sabbatini F et al

When they were retested after three and six months, individuals taking Pycnogenol had significant improvement in inner ear blood flow, compared to the placebo group

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It is generally supposed that O 2 - is dismutated spontaneously to H 2 O 2 due to the high local H + concentration, and that the highly permeable peroxide diffuses out of the digesting organelle to be handled by the antioxidant machinery