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Second, lactate can modify lysine residues of proteins by lactylation to regulate gene transcription (lactylation of histones) or modulate enzyme activity (lactylation of nonhistone proteins) [33,34,35]

GuptaPDuttVKaurNKalraPGuptaSDuaAet al

Gerson Institute, gerson.org

Science 333 , 13031307 (2011)

Systemic effects do occur after local injections : measurable HPA-axis suppression commonly lasts 24 weeks (longer with higher doses/frequency), and short-term suppression of immune cell counts and cytokines is documented