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This intrinsic plasticity underlies not only the rapid emergence of resistance, the persistence of tumor heterogeneity, and the adaptive evolution of cancer

The above suggests the high potential of PDT targeting mitochondria

10.1007/s40009-019-00799-w 60 PetkauA.ChelackW

Collectively, targeted inhibition of SUV39H1 demonstrates efficacy in attenuating post-injury neointima formation, positioning it as a novel therapeutic candidate for proliferative vasculopathy including in-stent restenosis (31)