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261 Several PMO-based NADs have been approved for treating DMD, including eteplirsen (Exondys 51), 262 golodirsen (Vyondys 53 ), 80 viltolarsen (Viltepso ), 263 and casimersen (Amondys )

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Data and Code Availability Coordinates and structure files have been deposited in the Protein Data Bank (PDB) under accession number 22ID (ctUT3-C19)

10.1007/s00775-008-0404-5 J

On this basis, smart hydrogels can be engineered to carry antiangiogenic or antineurotrophic agents for targeted release in the subchondral or intraarticular microenvironment, thereby modulating the neurovascular axis, slowing cartilage degeneration, and relieving pain