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In addition to mtDNA and proteins, the phospholipid components of the mitochondrial membrane are particularly susceptible to ROS-induced oxidative attack, as high concentration of polyunsaturated fatty acids in mitochondrial phospholipids makes them a primary target for reaction with oxidants, resulting in the production of various byproducts of lipid peroxidation that interact with and inactivate, ETC components

doi: 10.1210/jc.2002-020369

Mechanistic interrogation of cell transformation in vitro : the transformics assay as an exemplar of oncotransformation

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