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Depressive symptoms could be relieved by N-methyl-d-aspartate (NMDA) receptor antagonists, group I metabotropic glutamate receptor (mGluR1 and mGluR5) antagonists, and positive modulators of -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (78)

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Smart et al., 2007)

For example, alterations of serotonin (5-HT) and/or the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) in serum and the brainstem and of 3,4-dihydroxyphenylacetic acid (DOPAC, a metabolite of dopamine) in the brainstem were observed in rats exposed to JP-5 or JP-8