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Differences between groups on the continuous covariates were compared using Students t -test or MannWhitney U test as appropriate based on the distributional characteristics, while the chi-square test or Fisher exact test for categorical variables

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This immunomodulatory effect of EPS-R1 significantly enhances the efficacy of ICIs, including anti-PD-1, anti-PD-L1, and anti-CTLA-4 antibodies, in treating CCL20-expressing colorectal tumors