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However, these effects represent nutrient-correction benefits restoring adequate levels in deficient individuals rather than pharmacological enhancements beyond normal function

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In addition, Daratumumab reduces the types of inhibitory cells in the TME of multiple myeloma, i.e., it consumes immuno-suppressive cells such as CD38 + MDSCs, Tregs, and Bregs, and enhances anti-tumor activity ( + Treg depletion and induce the proliferation and functional recovery of effector T cells ( Figure 2 )