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Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease

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As mentioned previously, statins increase the level of PCSK9 which reduces LDLR recycling and LDL-P clearance

Oeyen E, Van Mol K, Baggerman G, Willems H, Boonen K, Rolfo C, et al

Additionally, drugs like metformin and simvastatin, which can penetrate the blood-brain barrier and alter metabolic pathways, have shown great feasibility in the treatment of gliomas