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Sun and colleagues extended the mechanistic work to the APP/PS1 transgenic Alzheimers disease mouse model

Neuron 15, 791803

NO (nitric oxide) pathway In vitro studies have observed that BPC-157 can modulate nitric oxide synthase (NOS) activity in various cell models

Currently available histological data indicate a dramatic restoration of tyrosine hydroxylase (TH) staining in the substantia nigra (SN) following six weeks of ip Dihexa treatment, and three months of Dihexa treatment results in nearly 100% recovery of SN TH staining(see Figure 32 of Example 4)