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GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy

Endogenous tagging enables analysis of expression and avoids artifacts associated with ectopic overexpression

It helps reduce the stress of oxidation

High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited