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Additionally, p53 regulates the biogenesis of iron-sulfur clusters and the copper chelator glutathione, which are two critical components of the cuproptotic pathway, suggesting that this tumor suppressor might play a role in cuproptosis

Several transcription factors such as activator protein (AP-1), nuclear factor kappa B (NF-B), and predominantly the nuclear factor erythroid 2related factor 2 (Nrf2) are involved in the induction of antioxidant enzymes

The results are tabulated in Supplemental Information: Table S4, and the Area under the curve (AUC) is presented in Supplemental Information, figure S1A-C

Cysteine is further processed into glutathione (GSH) and hydrogen sulfide, both essential for cellular function and antioxidant defense

In addition, caffeic acid, a dietary antioxidant supplement- also result reduction of lipid peroxidation in UVB-induced mice skin [3]