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AMPTX-1 showed significantly impaired activity in the KO cells compared to the WT parental control, consistent with a functional role for DCAF16 in the mode of action of AMPTX-1 (Fig

Some damage may be permanent

qRTPCR and immunofluorescence confirmed reduced NFE2L2 RNA and protein expression in psoriatic lesions compared to normal skin (Fig

Another commenter asked that we continue to add new activities when appropriate to ensure that a diversity of activities with a manageable effort level are available for all clinicians