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Compared to conventional imaging probes in the visible region, fluorescence imaging in the NIR-II region (10001700 nm) exhibits deeper tissue penetration and higher spatiotemporal resolution due to reduced tissue autofluorescence and photon scatter, enhancing accuracy and reliability in disease detection [13], [14], [15], [16], [17], [18]

For example, 150 mg of R-ALA may produce similar plasma concentrations to 300 mg of racemic ALA

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The ZIP6/ZIP10 heteromer is also critical for triggering zinc-mediated mitosis, 156 forming a zinc-dependent mitotic complex consisting of ZIP6, ZIP10, pS 727 STAT3, and pS 38 Stathmin, which play roles in proven mitotic pathways