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The combination may result in additive or synergistic gastrointestinal distress, potentially severe enough to cause dehydration, electrolyte disturbances, or medication non-adherence

Notably, diagnosing nonproteinuric DN (NP-DN) presents particular difficulty as it does not follow the classic proteinuria-renal function decline progression pattern, causing traditional screening methods to often fail (Samsu, 2021)

Other enriched subsystems are N-glycan synthesis as well as degradation and glycolysis/gluconeogenesis

Frontiers in Psychiatry, 13 , 813304

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