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Despite the alarming prevalence and consequences of PN, there exists a gap in its diagnosis and management, particularly in the context of DPN

Lipotropic injections are generally not recommended during pregnancy or breastfeeding, for people with a known allergy to any component of the formulation (including B12/cobalt), for those with certain kidney or liver conditions, or for those with certain medical conditions

Oral Vitamin B12 may not provide adequate supplementation due to variations in metabolism and poor absorption

Safety and Tolerability Key Findings: AOD-9604 has been shown to be safe and well-tolerated in clinical trials, with no reported impact on IGF-1 levels or growth hormone pathways

Injection Frequency : For patients requiring frequent B12 injections, using a thinner gauge needle (especially for SC injections) can reduce tissue trauma and discomfort over time