Moreover, the glycocalyx maintains the integrity of the bloodbrain barrier and the vascular health of the central nervous system, influencing key processes such as blood flow regulation, inflammation, and vascular permeability (49)
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The nigrostriatal pathway is particularly vulnerable to oxidative stress, neuroinflammation, and genetic mutations (e.g., parkin) due to its high synaptic density, extensive unmyelinated axonal networks, and elevated metabolic demands (Hegarty et al., 2013
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