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52 In dendritic cells (DCs), SIRT1 modulates autophagy and cytokine secretion, enhancing antiviral responses while preventing excessive Th2/Th17-mediated inflammatory reactions

We further mutated these three sites to glutamic acid (E) to mimick the negatively charged succinylation modification

Medications such as methadone to combat opioid addictions are regulated by cytochrome P450 genotypes (e.g., CYP2B6) and can also impact treatment response to addiction