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Research documents that endothelial cells at injury sites produce SPARC protein containing GHK sequences, which upon breakdown releases GHK-containing peptides that stimulate cell proliferation and new vessel growth

Drug solutions, typically 5 mg/ml in HPLC-grade water (except for Dihexa, prepared in DMSO), were added to rat serum, and the mixture was incubated at 37C

Clin Cancer Res 8 : 620627 Maulik G, Madhiwala P, Brooks S, Ma PC, Kijima T, Tibaldi EV, Schaefer E, Parmar K, Salgia R (2002b) Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer

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All 3 compounds named above affect one particular biomarker of aging, telomere attrition, they have been shown to increase or at least maintain telomere length (Zhou et al 2021