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4.2 Cardiovascular and autonomic dysfunction Autonomic dysfunction is a hallmark nonmotor feature of PD and includes: Orthostatic hypotension (in up to 3040%)

Cellular overexpression of USP2 enhances PER1-mediated repression on CLOCK/BMAL1 transcriptional activity by promoting PER nuclear retention, and consistently, USP2 knockout mice exhibit increased cytoplasmic PER1 and dampened PER2 and REV-ERB rhythmicity (Yang et al., 2014)

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Husain MA, Laurent B, Plourde M

Furthermore, both conditions occur more frequently in females, with the average age of onset typically in the 30 s or 40 s (4, 10, 11, 18, 19)