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19,67,73,74 Newly proliferated reactive astrocytes form borders that separate damaged, inflamed, and fibrotic tissue from adjacent viable neural tissue, and during this border formation newly proliferated astrocytes become transcriptionally reprogrammed to adopt new cellular interactions with non-neural cells

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These tumors maintain redox homeostasis and DNA repair via metabolic self-sufficiency

DOI: 10.1038/nrn1583 Schwartz M et al (1990): Oral nifedipine in the treatment of hypertensive urgency: cerebrovascular accident following a single dose

ROS nano-scavengers can eliminate extracellular ROS in the tumor microenvironment to elicit an antitumor immunity and increase infiltration of T lymphocytes, resulting in highly potent antitumor effect in breast cancer 41