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Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M

This can cause muscle cramps, palpitations, and restlessness

For example, patients with lung cancer treated with Gefitinib, a first-generation epidermal growth factor receptor (EGFR) inhibitor, typically develop resistance after 9 to 15 months of progression-free survival

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The feedback inhibition of IGF-1 on further GH secretion stayed intact, preventing the GH excess that drives insulin resistance with direct injection