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Meanwhile, alterations in lipid metabolism have also been implicated in the pathophysiological feature of type 1 diabetes pregnancy [173]

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The molecular mechanisms of the HBD of IGFBP-2 needs to be determined, but the HBD is implicated in downregulating PTEN expression and activates IGF-I signaling pathway in osteoblasts, indicating that the effect of the HBD on bone acquisition is in part mediated by the reduction of PTEN expression in osteoblastic cells