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A1: Typically, 4 to 6 weekly sessions are recommended for noticeable skin lightening, with full benefits seen after consistent treatment

This study was reviewed and approved by the Ethics Committee of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine and the Chinese Clinical Trial Registry (ChiCTR2000039820)

When the treatments stopped, the symptoms worsened again

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HSC activation is associated with metabolic reprogramming toward mitochondrial oxidative phosphorylation 41 , whereas activation of differentiated myeloid cell is associated with increased glycolysis 43