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Researchers also suggest a potential connection to copper uptake in cells, which could support copper-dependent enzymatic processes

AMP-activated protein kinase (AMPK) signaling pathway activity decreases with aging

Note that in polyprotic molecules, such as GSH, the deprotonated form of the sulfur center will be determined by microscopic acid dissociation constants (see Acid dissociation constants of reacting functional groups section), which further complicates the kinetic analyses (74, 78, 79)