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Limitations of the Research Despite promising animal studies, key limitations remain: Human studies are sparse: Most research is conducted in rodents with few clinical trials

Research protocols measuring body composition or urinary methylnicotinamide excretion usually run 816 weeks to capture meaningful shifts

The entire body composition evidence base comes from preclinical mouse studies and cell culture experiments

HUBERMAN: Now, early in life, when we are infants, children, teenagers, and so on, we secrete tons of growth hormone, in particular, during the early hours of sleep each night