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In addition, sulforaphane is an HDAC inhibitor used to treat colorectal cancer that can inhibit tumor progression by targeting HDAC1 and HDAC2 [353, 354]

Notably, the circadian regulator BMAL1 has been found to directly target and activate the promoter region of the VEGF gene via E-boxes, thereby promoting VEGF expression 28

Evidence-based medicine: a movement in crisis

Recently, riluzole has initiated a phase II, placebo-controlled, randomized, double-blind, parallel, multicenter, prevention trial with adult stage II/III colorectal cancer patients treated with a simplified FOLFOX4 regimen in the adjuvant setting (NCT03722680)