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Pickart, L., Margolina, A., & Vasquez-Soltero, J

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IGF-1 is a highly anabolic peptide hormone responsible for: Muscle cell proliferation and repair Tendon and ligament regeneration Bone growth Glucose uptake in muscle cells Increased satellite cell activation Oral administration of MK-677 raised serum IGF-1 levels by over 60% in healthy adults without altering cortisol, insulin, or gonadotropin concentrations. Chapman et al., Clinical Pharmacology & Therapeutics This rise in IGF-1 is what leads to muscle growth, improved recovery, and increased physical resilience over time

doi:10.1016/s2468-1253(21)00024-8 114Live attenuated vaccines: avoid use in those who are clinically immunosuppressed

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