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This process can be activated by cellular changes, including DNA damage, mitochondrial damage, withdrawal of growth factors and estrogen signaling [17, 37]

Animal experiments have confirmed that PHGDH knockdown or treatment with its specific inhibitors effectively suppresses the growth of AML xenografts without significant toxicity to normal hematopoietic stem cells (95)

(PubMed) 147

Next, Cys58 nucleophilically attacks the sulfide of Cys58, releasing a GS- anion, which picks up a solvent proton and is released from the enzyme, forming the second GSH

Consequently, the development of safe and effective lipid-lowering agents has a high social and economic implications and has emerged as a focal point of research worldwide