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10.5005/jp-journals-10024-1450 18 BerluttiF.PantanellaF.NataliziT.FrioniA.PaesanoR.PolimeniA.et al (2011)

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[0543] In one embodiment, the CAR of the invention comprises an anti- ALPP/ALPPL2 scFv (e.g., M25AD, M25ADX, M25, etc.), a human CD 8 hinge and transmembrane domain, and human 4- IBB and CD3zeta signaling domains