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Compared with that of peripheral vessels, BBB permeability is much less, generally allowing passive diffusion of lipophilic molecules less than 500 Da and few hydrogen-bonded donors and/or acceptors under physiological conditions (42, 43)

Mechanistic biochemical studies

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That said, researchers may find it useful to have a bit of background on past GHK-Cu dosing protocols: Minimum Effective Dose The lowest known doses of GHK-Cu administered to test subjects involve the application of skin creams and topical ointments