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The lactate accumulation from aerobic glycolysis acidifies the TME and promotes the M2 tumor-associated macrophage (TAM) polarization of these macrophages and microglial cells

The lower levels of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins observed in mice lacking SCAP highlight the critical role of cholesterol in mediating vesicle fusion with the presynaptic membrane (van Deijk et al., 2017)

Semi-solid cultures were incubated for four weeks at 24 2 C under either complete darkness or a 16-hour photoperiod

In animal experiments, increases in VEGF were observed at both 2 h and 1 month following TBI, indicating impaired vascularity in both the short and long term (120, 121)