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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

A landmark study by Regland et al

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Metabolic basis for the diabetogenic action of growth hormone in the obese ( ob / ob ) mouse Endocrinology 1987 120 : 15681575

During aging, GPAT activity was found to be blunted in murine T-lymphocytes [45], and GPAT1 deletion in T-lymphocytes induced a phenotype similar to that of aging [46]