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These therapeutic approaches are currently regarded as experimental and off-label, and patients should be fully informed of the limited empirical support for their efficacy and safety in these contexts

Metformin is the preferred initial glucose-lowering agent for treating type 2 diabetes mellitus (T2DM).1 With more than 80 million prescriptions for metformin filled per year, it is the most commonly used T2DM medication in the United States

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The above observation suggests that a hominid species or a modified mouse carrying the human Met gene seems essential, to examine the human therapeutic efficacy of these dimeric macrocycles in future animal experiments

Becker et al