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Gln is also converted to alpha-ketoglutarate (aKG) by multiple enzymes to enable ATP production through the tricarboxylic acid (TCA) cycle 10,11

Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell death To examine how the declines in GCLC and glutathione might affect brain homeostasis, we prepared GCLC floxed X CaMKII-Cre (GCLC-KO) mice whose GCLC expression is deleted in calcium/calmodulin-dependent protein kinase II (CaMKII)-positive neurons

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Glutathione has actually been shown to help stabilise and enhance the performance of other antioxidants such as vitamin C, even in low concentrations

They have both enzymatic as well as non-enzymatic defense systems against ROS