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Selectivity Advantage: Unlike GHRP-2 and GHRP-6, which non-selectively activate multiple pituitary hormone pathways (ACTH, cortisol, prolactin), ipamorelin demonstrates minimal cross-reactivity with non-target pituitary receptors, making it pharmacologically similar to GHRH in its hormone-releasing selectivity

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and dysregulated dopaminergic signaling and blunted reward response in the nucleus accumbens (Slcudean et al., 2025)