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Its anti-inflammatory activity is mainly mediated by the inhibition of lipopolysaccharide-induced expression of iNOS and COX-2 in mouse macrophages (RAW 264.7) or by the inhibition of superoxide anion release from human neutrophils FMLP/CB and elastin

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In studies with rats, both crude flavonoids and fraction B from lemons significantly reduced SBP

Discussion Iron homeostasis is essential to maintain cardiac function, and dysfunction of iron metabolism has been implicated in various cardiovascular diseases ( 2+ via L-type Ca 2+ channels, which are abundant in the heart