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maximum total score 16) based on the following criteria: 0, no visible swelling, erythema, or joint deformity

Coffee and green tea as a large source of antioxidant polyphenols in the Japanese population

These patients rely solely on their innate antiviral immune responses in the first stages of infection, which increases the risk of cytokine storms, severe disease onset, and mortality (Wang et al., 2020a)

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Further research is needed to elucidate the basic mechanism underpinning T and B-cell recruitment into an immune response, to examine antibody affinity maturation and to identify the determinants of the immunodominance hierarchy for T and B-cell epitopes, which ultimately may enable vaccine antigens to be rationally designed to induce broadly targeted immunity