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The result is a compound with dramatically superior pharmacokinetics: once-weekly dosing and 5 the weight loss of pramlintide

These compounds are FDA-approved (semaglutide and tirzepatide), extensively studied in large human trials, and produce 10-24% body weight reductions depending on the specific drug

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For esophageal tissue repeatedly exposed to acidic gastric contents, this protective effect prevents new damage while repair processes address existing injury

Philos Trans R Soc Lond B Biol Sci 370 , 20140087 (2015)