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Jens Haggstrom ironically debunked this new dumbed-down concept when he stated in another recently published article: "Many common echocardiographic variables are presumed to be influenced by breed, and breed-specific reference ranges are likely to be more accurate than ranges generated from dogs of all-breeds." Since there exist no cited published research studies of species-wide minimum measurements of enlarged left atriums and left ventricles, the next question is: How did the EPIC Study investigators arrive at these minimums, and why not rely upon the examining cardiologist's tried-and-true clinical means of determining if an MVD-affected dog's heart is enlarged or not

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(2017) Impairment of the carnitine/organic cation transporter 1ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease