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Although they are asymptomatic and referred to as silent, these mucus plugs are associated with worse functional, structural, and clinical disease measures, including reduced FEV 1 , worse exercise capacity, greater emphysema, thicker airway walls, and a higher likelihood of severe exacerbation [44]

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For the serum protein secretion and CYP activity data, a Student's t-test was used to analyze the statistical significance of differences between two groups