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Sections were incubated with primary antibodies in PBS overnight at 4 C for immunohistochemistry

As it turns out, the pathogenic bacteria are more sensitive to higher pH rinses whereas the commensal bacteria are less affected by the higher pH mouthwashes

This overstimulates NMDARs and AMPARs, causing excessive Ca + influx, neuronal depolarization, and the activation of voltage-gated Ca + and Na + channels

Furthermore, recent CRISPRCas9 knockout screening led to the identification of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1), which is as an important contributor to the defense system against ferroptosis (Fig

These findings suggest that AST protects dopaminergic neurons through suppression of ER stress and stabilization of the miR-7/SNCA regulatory loop, presenting a promising target for PD therapy ( In summary, AST demonstrates promising therapeutic potential in PD by targeting key pathological mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction