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Acknowledgments We thank Kerry af Forselles of afPharmative Insights for critical reading of this review

Consequently, mutated KRAS has been suggested as a major oncogenic driving factor and a reliable negative biomarker for predicting the efficacy of anti-EGFR agents in CRCs

Of note is that the results of this trial are somewhat conflicting, and the study design does not allow the effects of riboflavin and niacin to be differentiated