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Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen ( 2.2 Damage to biomolecules ROS can damage various cell biomolecules, including lipids, proteins, and DNA

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In addition, it inhibits the dysfunction of hepatic stellate cells and myofibroblasts, impedes viral replication in the liver, and facilitates the expression of factors with growth inhibitory effects while participating in the precise regulation of transcription factor activity (158)

Despite the importance of subungual melanoma, there is lack of systematic review on this topic in recent years