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SLOS patients are characterized by cholesterol deficiency and increased levels of cholesterol precursors and their metabolites [393, 394]

270:9459-9471 (1995).) Moreover, the polypeptides of the present invention can be fused to marker sequences (also referred to as tags)

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The basal-out phenotype of these organoids, cultured in the presence of BME, inverted within 12 h to a basal-in phenotype following exposure to AIIB2 (Fig